Metronidazole

introduction
Metronidazole is antibakteri and antiprotozoa synthetic derivat nitroimidazoi that have bakterisid, amebisid and trikomonosid activities.

How is it work
Cells or microorganisms in the metronidazole reduction into polar products. The results of this Reduction action have any way of preventing the antibakteri Sintesa nukleat acid.

Metronidazole effective against Trichomonas vaginalis, Entamoeba histolytica, Gierdia lamblia. Metronidazole work effectively both local and systemic.

Indikasi Indications

Metronidazole effective treatment for:
1. Trikomoniasis, such as uretritis and vaginitis that caused by Trichomonas vaginalis.
2. Amebiasis, such as amebiasis intestinal amebiasis and hepatic caused by E.histolytica.
3. The choice as the drug for giardiasis.

Side effects
Nausea, headache, anoreksia, diarrhea, constipation and painful epigastrum.

Medication interaction
Metronidazole prevent warfarin metabolism and other antikoagulan kumarin dose should be reduced.

The provision of alcohol during therapy with metronidazole can cause symptoms such as disulfiram, namely nausea, vomiting, stomach pain and headache.

With the drugs that press enzyme activity mikrosomal such as heart simetidina, will extend the part-time metronidazole.